That is pain, which seems to be a very important issue for human beings. As for myself, I am certainly not immune to pain, but am not interested in it. Yes pain happens from time to time, but as it is passing, I am aware that it is not permanent. In this respect I am lucky because many people suffer all the time and never have a break from the experience. I would say that life is mostly a neutral experience with outbreaks of pleasure and pain from time to time.